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Bee Venom Nanoparticles Kill HIV - 04/24/2013
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This powerful product from honey bees has been used since Hippocrates for treating conditions such as arthritis and rhumatism and recently for Parkinsons. But this new research, using only Melittin, one of the many components of bee venom , is taking our understanding of its potential to another level... Nanoparticles loaded with bee venom kill HIV AntivirTher . 2013;18(1):95-103. doi: 10.3851/IMP2346. Epub 2012 Sep 6. BACKGROUND : We investigated whether cytolytic melittin peptides could inhibit HIV-1 infectivity when carried in a nanoparticle construct that might be used as a topical vaginal virucide. Free melittin and melittin-loaded nanoparticles were prepared and compared for cytotoxicity and their ability to inhibit infectivity by CXCR4 and CCR5 tropic HIV-1 strains. METHODS : TZM-bl reporter cells expressing luciferase under the control of the HIV-1 promoter were incubated with HIV-1 NLHX (CXCR4) or HIV-1 NLYU2 (CCR5) viral strains and different doses of soluble CD4 (positive control) or free melittin to determine infectivity and viability. Melittin-loaded nanoparticles were formulated and different doses tested against VK2 vaginal epithelial cells to determine cell viability. Based on VK2 viability, melittin nanoparticles were tested for prevention of CXCR4 and CCR5 tropic HIV-1 infectivity and viability of TZM-bl reporter cells. Low-speed centrifugation was used to compare the ability of blank non-melittin nanoparticles and melittin nanoparticles to capture CCR5 tro...

Bee Venom Nanoparticles Kill HIV



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