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Propolis Flavonoid Has Chemotherapeutic Effect - 01/16/2013
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Propolis has numerous flavonoids, each with certain properties, frequently with overlapping qualities. Such is the case with Galangin, a flavonoid commonly identified in areas where Poplar trees are present. It's also possesses antimicrobial, antimycotic (anti-fungal), bacteriostatic and wound healing properties...  Galangin Induces B16F10 Melanoma Cell Apoptosis Via Mitochondrial Pathway and Sustained Activation of p38 MAPK Cytotechnology , 2012 Sep 22 Galangin , an active flavonoid present at high concentration in Alpinia officinarum Hance and propolis, shows cytotoxicity towards several cancer cell lines, including melanoma . However, the specific cellular targets of galangin-induced cytotoxicity in melanoma are still unknown. Here, we investigated the effects of galangin in B16F10 melanoma cells and explored the possible molecular mechanisms. Galangin significantly decreased cell viability of B16F10 cells, and also induced cell apoptosis shown by Hoechst 33342 staining and Annexin V-PI double staining flow cytometric assay. Furthermore, upon galangin treatment, disruption of mitochondrial membrane potential was observed by JC-1 staining. Western blotting analysis indicated that galangin activated apoptosis signaling cascades by cleavage of procaspase-9, procaspase-3 and PARP in B16F10 cells. Moreover, galangin significantly induced activation of phosphor-p38 MAPK in a time and dose dependent manner. SB203580, an inhibitor of p38, partially attenuated galangin-induce...

Propolis Flavonoid Has Chemotherapeutic Effect



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